منابع مشابه
Oncogenes and cancer.
From the Department of Molecular Virology, Immunology, and Medical Genetics and the Human Cancer Genetics Program, Ohio State University Medical Center, Columbus. Address reprint requests to Dr. Croce at the Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center, 385L Wiseman Hall, 400 W. 12th Ave., Columbus, OH...
متن کاملOncogenes and the molecular biology of cancer
Gene transfer experiments have made it possible to detect active transforming sequences in the DNA of various human tumor cells. These sequences, the cellular oncogenes, have been found in tumors as diverse as neuroblastomas, leuke-mias, carcinomas, and sarcomas. They appear to represent molecular determinants that participate in transformation mechanisms that are common to a wide variety of tu...
متن کاملHereditary Cancer , Oncogenes , and Antioncogenes 1 Alfred
cancer; (b) agents that can change the host genome by mutagenesis or by addition or deletion of genetic material should increase this background incidence; (c) abnormalities that favor either spontaneous or induced mutations should impose an elevated risk of cancer; and (d) inheritance of an initiating muta tion should strongly predipose to cancer. Consequently, there should be 4 groups of pers...
متن کاملHereditary Cancer , Oncogenes , and Antioncogenes 1
cancer; (b) agents that can change the host genome by mutagenesis or by addition or deletion of genetic material should increase this background incidence; (c) abnormalities that favor either spontaneous or induced mutations should impose an elevated risk of cancer; and (d) inheritance of an initiating muta tion should strongly predipose to cancer. Consequently, there should be 4 groups of pers...
متن کاملOncogenes, anti-oncogenes and the immune response to cancer: a mathematical model.
We develop a mathematical model for the initial growth of a tumour after a mutation in which either an oncogene is expressed or an anti-oncogene (i.e. tumour suppressor gene) is lost. Our model incorporates mitotic control by several biochemicals, with quite different regulatory characteristics, and we consider mutations affecting the cellular response to these control mechanisms. Our mathemati...
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ژورنال
عنوان ژورنال: Gut
سال: 1988
ISSN: 0017-5749
DOI: 10.1136/gut.29.4.417